G21A (p.Gly21Ala) variant of DRD4 (D(4) dopamine receptor)
G21A (p.Gly21Ala) in DRD4 (D(4) dopamine receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
G21A (p.Gly21Ala) variant details
- p.Gly21Ala
- gnomAD 11-637366-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.296
- REVEL 0.13
- MetaLR 0.11
- MetaSVM -0.98
- CADD 0.14
- PolyPhen-2 0.30
- SIFT 0.28
- Most common in the REMAINING population (allele frequency 2.4e-05)
- Structural context available
- Literature evidence available