G11W (p.Gly11Trp) variant of DRD4 (D(4) dopamine receptor)
G11W (p.Gly11Trp) in DRD4 (D(4) dopamine receptor) is a missense change. Clinical records from EBI and UniProt describe it as benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
G11W (p.Gly11Trp) variant details
- p.Gly11Trp
- 1000Genomes rs189482961
- ExAC rs189482961
- TOPMed rs189482961
- gnomAD rs189482961
- Benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.188
- REVEL 0.10
- AlphaMissense 0.14
- MetaLR 0.18
- MetaSVM -0.92
- CADD 8.51
- PolyPhen-2 0.44
- EBI: Benign
- UniProt: Benign
- Most common in the African/African-American population (allele frequency 0.00022)
- Structural context available