A22T (p.Ala22Thr) variant of DRD4 (D(4) dopamine receptor)
A22T (p.Ala22Thr) in DRD4 (D(4) dopamine receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
A22T (p.Ala22Thr) variant details
- p.Ala22Thr
- TOPMed rs1012641552
- gnomAD rs1012641552
- Missense
- Variant Prioritization Score for Impact Estimate 0.118
- REVEL 0.04
- AlphaMissense 0.09
- MetaLR 0.14
- MetaSVM -1.04
- CADD 6.56
- PolyPhen-2 0.01
- Most common in the Latino/Admixed American population (allele frequency 8.7e-05)
- Structural context available