A22S (p.Ala22Ser) variant of DRD4 (D(4) dopamine receptor)
A22S (p.Ala22Ser) in DRD4 (D(4) dopamine receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data and structural context.
A22S (p.Ala22Ser) variant details
- p.Ala22Ser
- TOPMed rs1012641552
- gnomAD rs1012641552
- Missense
- Variant Prioritization Score for Impact Estimate 0.115
- REVEL 0.05
- AlphaMissense 0.07
- MetaLR 0.14
- MetaSVM -1.04
- CADD 3.32
- PolyPhen-2 0.01
- Most common in the East Asian population (allele frequency 0.0016)
- Structural context available