W85C (p.Trp85Cys) variant of DRD3 (Dopamine receptor D3)
W85C (p.Trp85Cys) in DRD3 (Dopamine receptor D3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.74 / 1. The record also includes population frequency data and structural context.
W85C (p.Trp85Cys) variant details
- p.Trp85Cys
- rs76256558
- NCI-TCGA Cosmic COSV5568
- cosmic curated COSV55680
- Ensembl rs76256558
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.737
- REVEL 0.68
- ESM-1b 1.00
- AlphaMissense 0.86
- MetaLR 0.58
- MetaSVM 0.27
- CADD 29.80
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available