V91M (p.Val91Met) variant of DRD3 (Dopamine receptor D3)
V91M (p.Val91Met) in DRD3 (Dopamine receptor D3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data and structural context.
V91M (p.Val91Met) variant details
- p.Val91Met
- NCI-TCGA Cosmic COSV5568
- NCI-TCGA Cosmic COSV9987
- cosmic curated COSV99879
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.764
- REVEL 0.73
- ESM-1b 1.00
- AlphaMissense 0.44
- MetaLR 0.59
- MetaSVM 0.31
- CADD 33.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Middle Eastern population (allele frequency 0.00017)
- Structural context available