T108S (p.Thr108Ser) variant of DRD3 (Dopamine receptor D3)
T108S (p.Thr108Ser) in DRD3 (Dopamine receptor D3) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
T108S (p.Thr108Ser) variant details
- p.Thr108Ser
- gnomAD rs1242844218
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.41
- REVEL 0.31
- ESM-1b 0.00
- AlphaMissense 0.32
- MetaLR 0.13
- MetaSVM -0.90
- CADD 23.30
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the East Asian population (allele frequency 5e-05)
- Structural context available