M112L (p.Met112Leu) variant of DRD3 (Dopamine receptor D3)
M112L (p.Met112Leu) in DRD3 (Dopamine receptor D3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
M112L (p.Met112Leu) variant details
- p.Met112Leu
- TOPMed rs1349098291
- gnomAD rs1349098291
- Missense
- Variant Prioritization Score for Impact Estimate 0.599
- REVEL 0.58
- ESM-1b 1.00
- AlphaMissense 0.33
- MetaLR 0.34
- MetaSVM -0.57
- CADD 26.10
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available