L121I (p.Leu121Ile) variant of DRD3 (Dopamine receptor D3)
L121I (p.Leu121Ile) in DRD3 (Dopamine receptor D3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.80 / 1. The record also includes population frequency data and structural context.
L121I (p.Leu121Ile) variant details
- p.Leu121Ile
- 1000Genomes rs201447792
- Missense
- Variant Prioritization Score for Impact Estimate 0.797
- REVEL 0.78
- ESM-1b 1.00
- AlphaMissense 0.74
- MetaLR 0.73
- MetaSVM 0.69
- CADD 26.50
- Most common in the 1KG:JPT population (allele frequency 0.0049)
- Structural context available