L109R (p.Leu109Arg) variant of DRD3 (Dopamine receptor D3)
L109R (p.Leu109Arg) in DRD3 (Dopamine receptor D3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
L109R (p.Leu109Arg) variant details
- p.Leu109Arg
- Ensembl rs756246784
- Missense
- Variant Prioritization Score for Impact Estimate 0.654
- REVEL 0.67
- ESM-1b 1.00
- AlphaMissense 0.89
- MetaLR 0.39
- MetaSVM -0.02
- CADD 28.00
- Most common in the Non-Finnish European population (allele frequency 7.2e-06)
- Structural context available