F45Y (p.Phe45Tyr) variant of DRD3 (Dopamine receptor D3)
F45Y (p.Phe45Tyr) in DRD3 (Dopamine receptor D3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes structural context.
F45Y (p.Phe45Tyr) variant details
- p.Phe45Tyr
- NCI-TCGA Cosmic COSV5567
- cosmic curated COSV55679
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.416
- REVEL 0.34
- ESM-1b 1.00
- AlphaMissense 0.80
- MetaLR 0.16
- MetaSVM -0.80
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Structural context available