A59S (p.Ala59Ser) variant of DRD3 (Dopamine receptor D3)
A59S (p.Ala59Ser) in DRD3 (Dopamine receptor D3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
A59S (p.Ala59Ser) variant details
- p.Ala59Ser
- NCI-TCGA Cosmic COSV9987
- cosmic curated COSV99879
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.238
- REVEL 0.06
- ESM-1b 1.00
- AlphaMissense 0.08
- MetaLR 0.15
- MetaSVM -0.97
- CADD 10.70
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 5e-05)
- Structural context available