R145S (p.Arg145Ser) variant of DRD2 (D(2) dopamine receptor)
R145S (p.Arg145Ser) in DRD2 (D(2) dopamine receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data and structural context.
R145S (p.Arg145Ser) variant details
- p.Arg145Ser
- ExAC rs779267865
- TOPMed rs779267865
- gnomAD rs779267865
- Missense
- Variant Prioritization Score for Impact Estimate 0.689
- REVEL 0.69
- MetaLR 0.57
- MetaSVM 0.16
- CADD 24.70
- PolyPhen-2 0.97
- SIFT 0.10
- Most common in the Latino/Admixed American population (allele frequency 0.00013)
- Structural context available