L4R (p.Leu4Arg) variant of DRD2 (D(2) dopamine receptor)
L4R (p.Leu4Arg) in DRD2 (D(2) dopamine receptor) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
L4R (p.Leu4Arg) variant details
- p.Leu4Arg
- ExAC rs755896787
- gnomAD rs755896787
- Missense
- Variant Prioritization Score for Impact Estimate 0.384
- REVEL 0.33
- MetaLR 0.18
- MetaSVM -0.83
- CADD 23.70
- PolyPhen-2 0.01
- SIFT 0.05
- Most common in the REMAINING population (allele frequency 3.3e-05)
- Structural context available