Y109S (p.Tyr109Ser) variant of DPYD (Q12882)
Y109S (p.Tyr109Ser) in DPYD (Q12882) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.77 / 1. The record also includes population frequency data and structural context.
Y109S (p.Tyr109Ser) variant details
- p.Tyr109Ser
- gnomAD rs1312400771
- Missense
- Variant Prioritization Score for Impact Estimate 0.768
- REVEL 0.91
- MetaLR 0.74
- MetaSVM 0.67
- CADD 27.80
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available