T132S (p.Thr132Ser) variant of DPYD (Q12882)
T132S (p.Thr132Ser) in DPYD (Q12882) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.66 / 1. The record also includes population frequency data and structural context.
T132S (p.Thr132Ser) variant details
- p.Thr132Ser
- 1000Genomes rs538336580
- ExAC rs538336580
- gnomAD rs538336580
- Missense
- Variant Prioritization Score for Impact Estimate 0.661
- REVEL 0.73
- MetaLR 0.73
- MetaSVM 0.49
- CADD 25.50
- PolyPhen-2 0.93
- SIFT 0.02
- Most common in the Ashkenazi Jewish population (allele frequency 7.7e-05)
- Structural context available