S133F (p.Ser133Phe) variant of DPYD (Q12882)
S133F (p.Ser133Phe) in DPYD (Q12882) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.76 / 1. The record also includes population frequency data and structural context.
S133F (p.Ser133Phe) variant details
- p.Ser133Phe
- NCI-TCGA Cosmic COSV6008
- cosmic curated COSV60083
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.764
- REVEL 0.73
- MetaLR 0.76
- MetaSVM 0.58
- CADD 29.70
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Finnish in Finland (FIN) population (allele frequency 3.8e-05)
- Structural context available