L16P (p.Leu16Pro) variant of DPYD (Q12882)
L16P (p.Leu16Pro) in DPYD (Q12882) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.78 / 1. The record also includes population frequency data and structural context.
L16P (p.Leu16Pro) variant details
- p.Leu16Pro
- ExAC rs764555085
- gnomAD rs764555085
- Missense
- Variant Prioritization Score for Impact Estimate 0.784
- REVEL 0.88
- MetaLR 0.74
- MetaSVM 0.66
- CADD 28.20
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 3.4e-06)
- Structural context available