K89E (p.Lys89Glu) variant of DPYD (Q12882)
K89E (p.Lys89Glu) in DPYD (Q12882) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
K89E (p.Lys89Glu) variant details
- p.Lys89Glu
- TOPMed rs672601289
- Missense
- Variant Prioritization Score for Impact Estimate 0.575
- REVEL 0.62
- AlphaMissense 0.65
- MetaLR 0.32
- MetaSVM -0.58
- CADD 28.10
- PolyPhen-2 1.00
- Most common in the Non-Finnish European population (allele frequency 5e-05)
- Structural context available