K34E (p.Lys34Glu) variant of DPYD (Q12882)
K34E (p.Lys34Glu) in DPYD (Q12882) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
K34E (p.Lys34Glu) variant details
- p.Lys34Glu
- ExAC rs769847078
- gnomAD rs769847078
- Missense
- Variant Prioritization Score for Impact Estimate 0.456
- REVEL 0.39
- MetaLR 0.37
- MetaSVM -0.28
- CADD 23.90
- PolyPhen-2 0.11
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available