H25R (p.His25Arg) variant of DPYD (Q12882)
H25R (p.His25Arg) in DPYD (Q12882) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
H25R (p.His25Arg) variant details
- p.His25Arg
- ExAC rs776662759
- TOPMed rs776662759
- gnomAD rs776662759
- Missense
- Variant Prioritization Score for Impact Estimate 0.329
- REVEL 0.27
- MetaLR 0.29
- MetaSVM -0.65
- CADD 19.80
- PolyPhen-2 0.00
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 5.8e-05)
- Structural context available