H25P (p.His25Pro) variant of DPYD (Q12882)
H25P (p.His25Pro) in DPYD (Q12882) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data and structural context.
H25P (p.His25Pro) variant details
- p.His25Pro
- ExAC rs776662759
- TOPMed rs776662759
- gnomAD rs776662759
- Missense
- Variant Prioritization Score for Impact Estimate 0.422
- REVEL 0.43
- MetaLR 0.34
- MetaSVM -0.53
- CADD 21.90
- PolyPhen-2 0.08
- SIFT 0.01
- Most common in the 1KG:IBS population (allele frequency 0.017)
- Structural context available