H25L (p.His25Leu) variant of DPYD (Q12882)
H25L (p.His25Leu) in DPYD (Q12882) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
H25L (p.His25Leu) variant details
- p.His25Leu
- ExAC rs776662759
- TOPMed rs776662759
- gnomAD rs776662759
- Missense
- Variant Prioritization Score for Impact Estimate 0.336
- REVEL 0.28
- MetaLR 0.23
- MetaSVM -0.80
- CADD 21.60
- PolyPhen-2 0.01
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available