C87F (p.Cys87Phe) variant of DPYD (Q12882)
C87F (p.Cys87Phe) in DPYD (Q12882) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.90 / 1. The record also includes population frequency data and structural context.
C87F (p.Cys87Phe) variant details
- p.Cys87Phe
- cosmic curated COSV60081
- 1000Genomes rs528152707
- ExAC rs528152707
- gnomAD rs528152707
- Missense
- Variant Prioritization Score for Impact Estimate 0.902
- REVEL 0.96
- MetaLR 1.00
- MetaSVM 0.93
- CADD 25.90
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 7.7e-05)
- Structural context available