A105T (p.Ala105Thr) variant of DPYD (Q12882)
A105T (p.Ala105Thr) in DPYD (Q12882) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
A105T (p.Ala105Thr) variant details
- p.Ala105Thr
- ESP rs150385342
- ExAC rs150385342
- gnomAD rs150385342
- Missense
- Variant Prioritization Score for Impact Estimate 0.339
- REVEL 0.25
- MetaLR 0.28
- MetaSVM -0.49
- CADD 23.40
- PolyPhen-2 0.36
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available