V59M (p.Val59Met) variant of DOCK8 (Q8NF50)
V59M (p.Val59Met) in DOCK8 (Q8NF50) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.62 / 1. The record also includes population frequency data and structural context.
V59M (p.Val59Met) variant details
- p.Val59Met
- TOPMed rs955740785
- gnomAD rs955740785
- Missense
- Variant Prioritization Score for Impact Estimate 0.617
- AlphaMissense 0.30
- MetaLR 0.15
- MetaSVM -0.90
- CADD 26.20
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available