S85T (p.Ser85Thr) variant of DNMT3A (Q9Y6K1)
S85T (p.Ser85Thr) in DNMT3A (Q9Y6K1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
S85T (p.Ser85Thr) variant details
- p.Ser85Thr
- ExAC rs760236260
- gnomAD rs760236260
- Missense
- Variant Prioritization Score for Impact Estimate 0.26
- REVEL 0.20
- MetaLR 0.54
- MetaSVM -0.33
- CADD 16.80
- PolyPhen-2 0.00
- SIFT 0.42
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available