P59R (p.Pro59Arg) variant of DNMT3A (Q9Y6K1)
P59R (p.Pro59Arg) in DNMT3A (Q9Y6K1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
P59R (p.Pro59Arg) variant details
- p.Pro59Arg
- NCI-TCGA Cosmic COSV5304
- Variant assessed as somatic; high impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.307
- REVEL 0.25
- MetaLR 0.55
- MetaSVM -0.02
- CADD 22.70
- PolyPhen-2 0.10
- SIFT 0.15
- UniProt: Variant assessed as somatic; high impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available