P2L (p.Pro2Leu) variant of DNMT3A (Q9Y6K1)
P2L (p.Pro2Leu) in DNMT3A (Q9Y6K1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
P2L (p.Pro2Leu) variant details
- p.Pro2Leu
- cosmic curated COSV53076
- Missense
- Variant Prioritization Score for Impact Estimate 0.552
- REVEL 0.47
- MetaLR 0.71
- MetaSVM 0.61
- CADD 24.90
- PolyPhen-2 0.71
- SIFT 0.00
- Population evidence available
- Structural context available