K35R (p.Lys35Arg) variant of DNMT3A (Q9Y6K1)
K35R (p.Lys35Arg) in DNMT3A (Q9Y6K1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
K35R (p.Lys35Arg) variant details
- p.Lys35Arg
- gnomAD rs2033350122
- Missense
- Variant Prioritization Score for Impact Estimate 0.349
- REVEL 0.22
- MetaLR 0.54
- MetaSVM -0.20
- CADD 22.50
- PolyPhen-2 0.00
- SIFT 0.07
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available