D25= variant of DNMT3A (Q9Y6K1)
D25= in DNMT3A (Q9Y6K1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; low impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
D25= variant details
- rs538820253
- NCI-TCGA Cosmic COSV5306
- NCI-TCGA Cosmic COSV5308
- Variant assessed as somatic; low impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.41
- AlphaMissense 0.06
- MetaLR 0.34
- MetaSVM -0.70
- PolyPhen-2 0.00
- SIFT 1.00
- MutPred 0.30
- UniProt: Variant assessed as somatic; low impact.
- Population evidence available
- Structural context available