D22G (p.Asp22Gly) variant of DNMT3A (Q9Y6K1)
D22G (p.Asp22Gly) in DNMT3A (Q9Y6K1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
D22G (p.Asp22Gly) variant details
- p.Asp22Gly
- cosmic curated COSV53076
- Missense
- Variant Prioritization Score for Impact Estimate 0.351
- REVEL 0.22
- MetaLR 0.58
- MetaSVM 0.26
- CADD 22.90
- PolyPhen-2 0.05
- SIFT 0.34
- Most common in the Non-Finnish European population (allele frequency 9.3e-07)
- Structural context available