A17S (p.Ala17Ser) variant of DNMT3A (Q9Y6K1)
A17S (p.Ala17Ser) in DNMT3A (Q9Y6K1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
A17S (p.Ala17Ser) variant details
- p.Ala17Ser
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.319
- REVEL 0.26
- MetaLR 0.57
- MetaSVM -0.52
- CADD 15.40
- PolyPhen-2 0.00
- SIFT 0.87
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available