Y190C (p.Tyr190Cys) variant of DLG4 (Disks large homolog 4)

Name: DLG4 Y190C (p.Tyr190Cys) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-20
License: https://catvariant.com/terms-of-use

Y190C (p.Tyr190Cys) in DLG4 (Disks large homolog 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.69 / 1. The record also includes population frequency data.

Y190C (p.Tyr190Cys) variant details

p.Tyr190Cys
NCI-TCGA Cosmic COSV1002
cosmic curated COSV10026
gnomAD rs2070253586
Variant assessed as somatic; moderate impact.
Missense
Variant Prioritization Score for Impact Estimate 0.687
REVEL 0.70
CADD 28.70
PolyPhen-2 1.00
SIFT 0.04
UniProt: Variant assessed as somatic; moderate impact.
Most common in the Finnish in Finland (FIN) population (allele frequency 9.4e-05)