G89S (p.Gly89Ser) variant of DLG4 (Disks large homolog 4)
G89S (p.Gly89Ser) in DLG4 (Disks large homolog 4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G89S (p.Gly89Ser) variant details
- p.Gly89Ser
- rs868786374
- NCI-TCGA Cosmic COSV5724
- cosmic curated COSV57242
- TOPMed rs868786374
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.374
- REVEL 0.09
- CADD 23.50
- PolyPhen-2 0.92
- SIFT 0.07
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- DLG4 PDZ domain domainome 1.0: score -0.169