T66S (p.Thr66Ser) variant of DICER1 (Endoribonuclease Dicer)
T66S (p.Thr66Ser) in DICER1 (Endoribonuclease Dicer) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided; Hereditary cancer-predisposing syndrome; DICER1-related tumor pred. The record also includes published literature and structural context.
T66S (p.Thr66Ser) variant details
- p.Thr66Ser
- rs777362732
- ClinGen CA390890006
- ClinVar RCV001207613
- ClinVar RCV002418697
- Uncertain significance
- not provided; Hereditary cancer-predisposing syndrome; DICER1-related tumor pred
- Missense
- ClinVar: Uncertain significance (not provided; Hereditary cancer-predisposing syndrome; DICER1-re)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- Cited in: DICER1-Related Tumor Predisposition. (PMID 24761742)
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)