T66I (p.Thr66Ile) variant of DEPDC5 (GATOR1 complex protein DEPDC5)
T66I (p.Thr66Ile) in DEPDC5 (GATOR1 complex protein DEPDC5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.73 / 1. The record also includes population frequency data, published literature, and structural context.
T66I (p.Thr66Ile) variant details
- p.Thr66Ile
- gnomAD 22-31764978-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.734
- CADD 23.40
- PolyPhen-2 0.20
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available