S23F (p.Ser23Phe) variant of DDX3X (ATP-dependent RNA helicase DDX3X)
S23F (p.Ser23Phe) in DDX3X (ATP-dependent RNA helicase DDX3X) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
S23F (p.Ser23Phe) variant details
- p.Ser23Phe
- NCI-TCGA Cosmic COSV6786
- cosmic curated COSV67863
- TOPMed rs2063786718
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.454
- REVEL 0.22
- ESM-1b 1.00
- AlphaMissense 0.25
- CADD 25.80
- PolyPhen-2 0.20
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 2.2e-05)
- Structural context available