R37C (p.Arg37Cys) variant of DDX3X (ATP-dependent RNA helicase DDX3X)
R37C (p.Arg37Cys) in DDX3X (ATP-dependent RNA helicase DDX3X) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
R37C (p.Arg37Cys) variant details
- p.Arg37Cys
- NCI-TCGA Cosmic COSV6786
- cosmic curated COSV67864
- Ensembl rs2063810957
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.511
- REVEL 0.28
- ESM-1b 1.00
- AlphaMissense 0.76
- CADD 24.20
- PolyPhen-2 0.35
- SIFT 0.07
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available