F65L (p.Phe65Leu) variant of DCX (O43602)
F65L (p.Phe65Leu) in DCX (O43602) is a missense change. Clinical records from EBI and UniProt describe it as likely pathogenic. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes structural context.
F65L (p.Phe65Leu) variant details
- p.Phe65Leu
- rs587783531
- ClinGen CA171881
- cosmic curated COSV57566
- ClinVar RCV000145819
- Likely pathogenic
- Missense
- Variant Prioritization Score for Impact Estimate 0.713
- AlphaMissense 1.00
- MetaLR 0.63
- MetaSVM 0.54
- SIFT 0.00
- EVE 0.79
- EBI: Likely pathogenic
- UniProt: Likely pathogenic
- Structural context available