W9C (p.Trp9Cys) variant of DCC (Netrin receptor DCC)
W9C (p.Trp9Cys) in DCC (Netrin receptor DCC) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
W9C (p.Trp9Cys) variant details
- p.Trp9Cys
- NCI-TCGA TCGA novel
- TOPMed rs1983595457
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.287
- REVEL 0.10
- MetaLR 0.08
- MetaSVM -1.07
- CADD 23.90
- PolyPhen-2 0.43
- SIFT 0.03
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available