S24R (p.Ser24Arg) variant of DCC (Netrin receptor DCC)
S24R (p.Ser24Arg) in DCC (Netrin receptor DCC) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
S24R (p.Ser24Arg) variant details
- p.Ser24Arg
- NCI-TCGA Cosmic COSV1014
- Ensembl rs1983598378
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.271
- REVEL 0.13
- MetaLR 0.07
- MetaSVM -1.08
- CADD 21.40
- PolyPhen-2 0.03
- SIFT 0.13
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available