R41C (p.Arg41Cys) variant of DCC (Netrin receptor DCC)
R41C (p.Arg41Cys) in DCC (Netrin receptor DCC) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
R41C (p.Arg41Cys) variant details
- p.Arg41Cys
- rs962808767
- NCI-TCGA Cosmic COSV5908
- cosmic curated COSV59089
- TOPMed rs962808767
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.487
- REVEL 0.35
- CADD 24.40
- PolyPhen-2 0.85
- SIFT 0.13
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available