M168T (p.Met168Thr) variant of DCC (Netrin receptor DCC)
M168T (p.Met168Thr) in DCC (Netrin receptor DCC) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as pathogenic in the context of Esophageal carcinoma, somatic. The record also includes variant effect predictions, published literature, and structural context.
M168T (p.Met168Thr) variant details
- p.Met168Thr
- rs121912967
- ClinGen CA127073
- ClinVar RCV000018604
- UniProt VAR 003909
- Pathogenic
- Esophageal carcinoma, somatic
- Missense
- MutPred 0.35
- ClinVar: Pathogenic (Esophageal carcinoma, somatic)
- EBI: Pathogenic (in a esophageal carcinoma)
- UniProt: Pathogenic (in a esophageal carcinoma)
- Structural context available
- Cited in: Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and… (PMID 8187090)