L5F (p.Leu5Phe) variant of DCC (Netrin receptor DCC)
L5F (p.Leu5Phe) in DCC (Netrin receptor DCC) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
L5F (p.Leu5Phe) variant details
- p.Leu5Phe
- TOPMed rs1273414468
- gnomAD rs1273414468
- Missense
- Variant Prioritization Score for Impact Estimate 0.344
- REVEL 0.18
- MetaLR 0.16
- MetaSVM -0.77
- CADD 26.00
- PolyPhen-2 0.97
- SIFT 0.13
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available