L59H (p.Leu59His) variant of DCC (Netrin receptor DCC)
L59H (p.Leu59His) in DCC (Netrin receptor DCC) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data, published literature, and structural context.
L59H (p.Leu59His) variant details
- p.Leu59His
- gnomAD 18-52752138-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.609
- REVEL 0.59
- CADD 24.70
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available