L58F (p.Leu58Phe) variant of DCC (Netrin receptor DCC)
L58F (p.Leu58Phe) in DCC (Netrin receptor DCC) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, published literature, and structural context.
L58F (p.Leu58Phe) variant details
- p.Leu58Phe
- gnomAD 18-52752134-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.249
- REVEL 0.07
- CADD 14.50
- PolyPhen-2 0.04
- SIFT 0.17
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available