L40P (p.Leu40Pro) variant of DCC (Netrin receptor DCC)
L40P (p.Leu40Pro) in DCC (Netrin receptor DCC) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
L40P (p.Leu40Pro) variant details
- p.Leu40Pro
- NCI-TCGA Cosmic COSV1005
- cosmic curated COSV10050
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.407
- REVEL 0.25
- CADD 24.70
- PolyPhen-2 0.45
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available