L27P (p.Leu27Pro) variant of DCC (Netrin receptor DCC)
L27P (p.Leu27Pro) in DCC (Netrin receptor DCC) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
L27P (p.Leu27Pro) variant details
- p.Leu27Pro
- gnomAD 18-52340867-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.298
- REVEL 0.26
- MetaLR 0.11
- MetaSVM -0.98
- CADD 23.50
- PolyPhen-2 0.17
- SIFT 0.25
- Most common in the Non-Finnish European population (allele frequency 6.3e-06)
- Structural context available
- Literature evidence available