L27F (p.Leu27Phe) variant of DCC (Netrin receptor DCC)
L27F (p.Leu27Phe) in DCC (Netrin receptor DCC) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
L27F (p.Leu27Phe) variant details
- p.Leu27Phe
- rs1208033056
- NCI-TCGA Cosmic COSV7142
- gnomAD rs1208033056
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.303
- REVEL 0.10
- MetaLR 0.10
- MetaSVM -1.08
- CADD 22.20
- PolyPhen-2 0.00
- SIFT 0.73
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available